Simulators give a virtual copy of a system. Simulation allows to understand the system’s behaviour processes. This is feasible thanks to a model (the core of the simulation process) that shows the relation between several major process variables (service levels, resources utilization, stocks level, etc.). The greatest advantage given by the use of simulators is that they are able to catch dynamism and randomness: two key elements that impact on all real processes and that are not so easily predictable. Simulation is a key tool to support decisions; it gives the opportunity to run and see its own system working in a virtual environment. In so doing, you can foresee the system behaviour when changing conditions and parameters; assess all indicators of technical and economic performance; optimize through what-if analysis; find the most appropriate solutions, reducing investment and operating costs and limiting risks. Therefore, simulation is an effective strategic and operational tool to support managers in decision making processes.